Drug-induced liver injury...... ( DILI )

Drug-induced liver injury (DILI) is an injury of the liver that may occur when you take certain medicines.

Examples :- 

• • Amiodarone
  • Anabolic steroids
  • Birth control pills
  • Chlorpromazine
  • Erythromycin
  • Halothane (a type of anesthesia)
  • Methyldopa
  • Isoniazid
  • Methotrexate
  • Statins
  • Sulfa drugs
  • Tetracyclines
  • Amoxicillin-clavulanate

  Some anti-seizure medicines

findings :-

• Abdominal pain
• Dark urine
• Diarrhea
• Fatigue
• Fever
• Headache
• Jaundice
• Loss of appetite
• Nausea and vomiting
• Rash
• White or clay-colored stools
• elevated liver enzymes 
• enlaged liver and right hypochonderial tenderness

Treatment :-

• The only specific treatment for most cases of liver damage caused by taking a drug is to stop taking the drug that caused the problem.

• However, if you took high doses of acetaminophen, you should get treated for liver injury in the emergency department or other acute treatment setting as soon as possible.

• If symptoms are severe, you should rest and avoid heavy exercise, alcohol, acetaminophen, and any other substances that might harm the liver. You may need to get fluids through a vein if nausea and vomiting are severe.

N.B:-  rarely complicated by liver failure