Catecholaminergic polymorphic ventricular tachycardia ( CPVT )

 It abnormal heart rythm in response to physical activity or emotional stress

• episodes of VT can cause light headedness, dizzeness, and syncope
• episodes begin in childhood
• if not recognized and treated, it may cause cardiac arrest leading to sudden death

Etiology

inherited disease

• If mutation in RYR2 gene, will inherited in the form of Autosomal dominant and it occure in 50% of cases
• If mutation in CASQ2 gene, will inherited in the form of Autosomal ressissive and occure in 5% of cases
• the both genes provide instructions for making protein that help in maintain normal heart beat by controlling calcium movement within myocytes