Mini Mental Status Examination MMSE to check for cognitive impairment

 

Peutz-Jegher Syndrome PJS

- It's inherited in an Autosomal Dominant pattern

- Due to mutation in STK11 gene [ also known as LKB1 ] which is tumor suppressor gene. 

       →   its mutations disrupting its ability to restrain the cell division       

 

- Characterestic by development of non-cutaneous growths called hamartomatous polyps in the 

   gastrointestinal tract particulary stomach and intestine 

- The polyps have a great risk of develop cancer

features

   childern with :-

  

            * Small dark-colored spots on the lips, around and inside the mouth, near the eya, nostril and 

 

               around the anus. also may found on hands and feet and often fade as the person gets older 

           * Multiple polyps in the stomach and intestine during the childhood and adolescnce 

           * Polyps may cause recurrent bowel obstructions, chronic bleeding and abdominal pain

           * The patient has the risk of developing types of cancers as 

                    " GIT    " Pancreas       " Cervix      " Ovary      " Breast

The patient diagnosed by clinical picture

            

CURB-65 SCORE for Assess Sevirity of Pneumonia

 

GRACE Risk Score to Assess the Mortality Rate after Acute Coronary Syndrome

 

Wells Score for Assess DVT / Pulmonary Embolism

 

Modified Duke Criteria for assess Infective Endocarditis

 

CHADS-VASC Score fot Atrial Fibrillation Stroke Risk